Performance of Confirmatory Tests for Diagnosing Primary Aldosteronism: a Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Confirmatory tests are recommended for diagnosing primary aldosteronism, but the supporting evidence is unclear.

Methods

We searched Medline, EMBASE, and the Cochrane Central Register of Controlled Trials. Studies evaluating any guideline-recommended confirmatory test (ie, saline infusion test, salt loading test, fludrocortisone suppression test, and captopril challenge test), compared with a reference standard were included. The Quality Assessment of Diagnostic Accuracy Studies-2 tool was used to assess the risk of bias. Meta-analyses were conducted using hierarchical summary receiver operating characteristic models.

Results

Fifty-five studies were included, comprising 26 studies (3654 participants) for the recumbent saline infusion test, 4 studies (633 pa

SUBMITTER: Leung AA 

PROVIDER: S-EPMC9278709 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature