Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na⁺/H⁺ Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway.

ABSTRACT:

Background

The present study directly tested the crucial role of intestinal gastrin/CCKBR (cholecystokinin B receptor) in the treatment of salt-sensitive hypertension.

Methods

Adult intestine-specific Cckbr-knockout mice (Cckbr^fl/fl villin-Cre) and Dahl salt-sensitive rats were studied on the effect of high salt intake (8% NaCl, 6-7 weeks) on intestinal Na^+/H⁺ exchanger 3 expression, urine sodium concentration, and blood pressure. High-salt diet increased urine sodium concentration and systolic blood pressure to a greater extent in Cckbr^fl/fl villin-Cre mice and Dahl salt-sensitive rats than their respective controls, Cckbr^fl/fl villin mice and SS13^BN rats. We c

SUBMITTER: Jiang X 

PROVIDER: S-EPMC9278716 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature