A pipeline for the reconstruction and evaluation of context-specific human metabolic models at a large-scale.

ABSTRACT: Constraint-based (CB) metabolic models provide a mathematical framework and scaffold for in silico cell metabolism analysis and manipulation. In the past decade, significant efforts have been done to model human metabolism, enabled by the increased availability of multi-omics datasets and curated genome-scale reconstructions, as well as the development of several algorithms for context-specific model (CSM) reconstruction. Although CSM reconstruction has revealed insights on the deregulated metabolism of several pathologies, the process of reconstructing representative models of human tissues still lacks benchmarks and appropriate integrated software frameworks, since many tools required for this process are still disperse across various software platforms, some of which are proprietary. In

SUBMITTER: Vieira V 

PROVIDER: S-EPMC9278738 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature