Angiotensin II induces reactive oxygen species, DNA damage, and T-cell apoptosis in severe COVID-19.

ABSTRACT:

Background

Lymphopenia is predictive of survival in patients with coronavirus disease 2019 (COVID-19).

Objective

The aim of this study was to understand the cause of the lymphocyte count drop in severe forms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Methods

Monocytic production of reactive oxygen species (ROSs) and T-cell apoptosis were measured by flow cytometry, DNA damage in PBMCs was measured by immunofluorescence, and angiotensin II (AngII) was measured by ELISA in patients infected with SARS-CoV-2 at admission to an intensive care unit (ICU) (n = 29) or not admitted to an ICU (n = 29) and in age- and sex-matched healthy controls.

Results

We showed that the monocytes of certain patients with COVID-19 spontaneously released

SUBMITTER: Kundura L 

PROVIDER: S-EPMC9278992 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature