Gene Expression Analysis Reveals Prognostic Biomarkers of the Tyrosine Metabolism Reprogramming Pathway for Prostate Cancer.

ABSTRACT:

Background

Tyrosine metabolism pathway-related genes were related to prostate cancer progression, which may be used as potential prognostic markers.

Aims

To dissect the dysregulation of tyrosine metabolism in prostate cancer and build a prognostic signature based on tyrosine metabolism-related genes for prostate cancer. Materials and Method. Cross-platform gene expression data of prostate cancer cohorts were collected from both The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Based on the expression of tyrosine metabolism-related enzymes (TMREs), an unsupervised consensus clustering method was used to classify prostate cancer patients into different molecular subtypes. We employed the least absolute shrinkage and selection operator (LASSO) Cox regress

SUBMITTER: Li W 

PROVIDER: S-EPMC9279037 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature