Different Fecal Microbiota in Hirschsprung's Patients With and Without Associated Enterocolitis.

ABSTRACT:

Background and objectives

Patients with Hirschsprung's disease are at risk of developing Hirschsprung-associated enterocolitis, especially in the first 2 years of life. The pathophysiology of this inflammatory disease remains unclear, and intestinal dysbiosis has been proposed in the last decade. The primary objective of this study was to evaluate in a large cohort if Hirschsprung-associated enterocolitis was associated with alterations of fecal bacterial composition compared with HD without enterocolitis in different age groups.

Methods

We analyzed the fecal microbiota structure of 103 Hirschsprung patients from 3 months to 16 years of age, all of whom had completed definitive surgery for rectosigmoid Hirschsprung. 16S rRNA gene sequencing allowed us to compare the microbio

SUBMITTER: Arnaud AP 

PROVIDER: S-EPMC9279138 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature