Core control principles of the eukaryotic cell cycle.

ABSTRACT: Cyclin-dependent kinases (CDKs) lie at the heart of eukaryotic cell cycle control, with different cyclin-CDK complexes initiating DNA replication (S-CDKs) and mitosis (M-CDKs)^1,2. However, the principles on which cyclin-CDK complexes organize the temporal order of cell cycle events are contentious³. One model proposes that S-CDKs and M-CDKs are functionally specialized, with substantially different substrate specificities to execute different cell cycle events^4-6. A second model proposes that S-CDKs and M-CDKs are redundant with each other, with both acting as sources of overall CDK activity^7,8. In this model, increasing CDK activity, rather than CDK substrate specificity, orders cell cycle events^9,10. Here we reconcile these two views

SUBMITTER: Basu S 

PROVIDER: S-EPMC9279155 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature