Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements.

ABSTRACT: Zebrafish, a popular organism for studying embryonic development and for modeling human diseases, has so far lacked a systematic functional annotation program akin to those in other animal models. To address this, we formed the international DANIO-CODE consortium and created a central repository to store and process zebrafish developmental functional genomic data. Our data coordination center ( https://danio-code.zfin.org ) combines a total of 1,802 sets of unpublished and re-analyzed published genomic data, which we used to improve existing annotations and show its utility in experimental design. We identified over 140,000 cis-regulatory elements throughout development, including classes with distinct features dependent on their activity in time and space. We delineated the distinct dista

SUBMITTER: Baranasic D 

PROVIDER: S-EPMC9279159 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature