Pseudocleavage furrows restrict plasma membrane-associated PH domain in syncytial Drosophila embryos.

ABSTRACT: Syncytial cells contain multiple nuclei and have local distribution and function of cellular components despite being synthesized in a common cytoplasm. The syncytial Drosophila blastoderm embryo shows reduced spread of organelle and plasma membrane-associated proteins between adjacent nucleo-cytoplasmic domains. Anchoring to the cytoarchitecture within a nucleo-cytoplasmic domain is likely to decrease the spread of molecules; however, its role in restricting this spread has not been assessed. In order to analyze the cellular mechanisms that regulate the rate of spread of plasma membrane-associated molecules in the syncytial Drosophila embryos, we express a pleckstrin homology (PH) domain in a localized manner at the anterior of the embryo by tagging it with the bicoid mRNA localization si

SUBMITTER: Thukral S 

PROVIDER: S-EPMC9279176 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature