In vivo evaluation of additively manufactured multi-layered scaffold for the repair of large osteochondral defects.

ABSTRACT: The repair of osteochondral defects is one of the major clinical challenges in orthopaedics. Well-established osteochondral tissue engineering methods have shown promising results for the early treatment of small defects. However, less success has been achieved for the regeneration of large defects, which is mainly due to the mechanical environment of the joint and the heterogeneous nature of the tissue. In this study, we developed a multi-layered osteochondral scaffold to match the heterogeneous nature of osteochondral tissue by harnessing additive manufacturing technologies and combining the established art laser sintering and material extrusion techniques. The developed scaffold is based on a titanium and polylactic acid matrix-reinforced collagen "sandwich" composite system. The micros

SUBMITTER: Tamaddon M 

PROVIDER: S-EPMC9279224 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature