Desymmetrization of N-Cbz glutarimides through N-heterocyclic carbene organocatalysis.

ABSTRACT: Over the past decade, the catalysis of N-heterocyclic carbenes has achieved significant advances. In this area, aldehydes, enals, and esters, are commonly employed as starting materials through various catalytic activation modes. However, NHC-activated strategy of amide and its derivatives remains elusive. Described herein is the realization of asymmetric desymmetrization of N-Cbz glutarimides with alcohols through an imide C-N bond cleavage under NHC organocatalysis. A structurally diverse set of enantioenriched 4-amido esters is generated with acceptable yields and high enantioselectivities. This method features mild reaction conditions, excellent substrate scope, and excellent atom economy. DFT calculations have been performed to explore the detailed reaction mechanism and the origin of

SUBMITTER: Hu Z 

PROVIDER: S-EPMC9279320 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature