Articular surface integrity assessed by ultrasound is associated with biological characteristics of articular cartilage in early-stage degeneration.

ABSTRACT: Early diagnosis of articular cartilage damage and repeated evaluation of treatment efficacy are essential for osteoarthritis treatment. In this study, we established a simple ultrasound grading system for early degenerative articular cartilage and investigated its relationship with cartilage biological characteristics. The ultrasound grading system were based on surface integrity (S1a: continuous high-echo lines, S1b: discontinuous or weak high-echo lines, S2: surface irregular) and cartilage echogenicity (E1: with > 50%, E2: < 50% hypoechoic area of total cartilage layer) and verified by surface roughness (Ra; μm) and histological staining. Ra was lower in S1 than in S2, and the percentage of hypoechoic and safranin O-stained areas was positively correlated. Then we examined its relations

SUBMITTER: Shi W 

PROVIDER: S-EPMC9279397 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature