Prediction of degradation pathways of phenolic compounds in the human gut microbiota through enzyme promiscuity methods.

ABSTRACT: The relevance of phenolic compounds in the human diet has increased in recent years, particularly due to their role as natural antioxidants and chemopreventive agents in different diseases. In the human body, phenolic compounds are mainly metabolized by the gut microbiota; however, their metabolism is not well represented in public databases and existing reconstructions. In a previous work, using different sources of knowledge, bioinformatic and modelling tools, we developed AGREDA, an extended metabolic network more amenable to analyze the interaction of the human gut microbiota with diet. Despite the substantial improvement achieved by AGREDA, it was not sufficient to represent the diverse metabolic space of phenolic compounds. In this article, we make use of an enzyme promiscuity approa

SUBMITTER: Balzerani F 

PROVIDER: S-EPMC9279433 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature