Proteomic profiling of plasma exosomes from patients with B-cell acute lymphoblastic leukemia.

ABSTRACT: We aimed to comprehensively investigate the proteomic profile and underlying biological function of exosomal proteins associated with B-cell acute lymphoblastic leukemia. Exosomes were isolated from plasma samples collected from five patients with B-ALL and five healthy individuals, and their protein content was quantitatively analyzed by liquid chromatography with tandem mass spectrometry. A total of 342 differentially expressed proteins were identified in patients with B-ALL. The DEPs were mainly associated with protein metabolic processes and protein activity regulation and were significantly enriched in the Notch and autophagy pathways. Furthermore, we found that ADAM17 and ATG3 were upregulated in patients with B-ALL and enriched in the Notch and autophagy pathways, respectively. Furt

SUBMITTER: Zhu S 

PROVIDER: S-EPMC9279438 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature