Preconditioning in hypoxic-ischemic neonate mice triggers Na⁺-Ca²⁺ exchanger-dependent neurogenesis.

ABSTRACT: To identify alternative interventions in neonatal hypoxic-ischemic encephalopathy, researchers' attention has been focused to the study of endogenous neuroprotective strategies. Based on the preconditioning concept that a subthreshold insult may protect from a subsequent harmful event, we aimed at identifying a new preconditioning protocol able to enhance Ca²⁺-dependent neurogenesis in a mouse model of neonatal hypoxia ischemia (HI). To this purpose, we also investigated the role of the preconditioning-linked protein controlling ionic homeostasis, Na⁺/Ca²⁺ exchanger (NCX). Hypoxic Preconditioning (HPC) was reproduced by exposing P7 mice to 20' hypoxia. HI was induced by isolating and cutting the right common carotid artery. A significant reduction in ischem

SUBMITTER: Brancaccio P 

PROVIDER: S-EPMC9279453 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature