Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells.

ABSTRACT: Luteinizing hormone (LH) stimulates the synthesis and secretion of the key steroid hormone estrogen, which subsequently promotes ovarian follicular growth and development. Therefore, the administration of exogenous LH to achieve superovulation (multiple ovulations) and an LH surge is commonly used as the most effective therapeutic option in a majority of in vitro fertilization (IVF) clinics. However, a relatively low pregnancy rate (between 20% and 35%) is one of the most challenging aspects of LH-based infertility treatment. Furthermore, the major cause of this low pregnancy rate in LH-based infertility treatment remains unidentified. Recent studies have shown that endometrial stem cell loss or deficiency can significantly decrease tissue regeneration ability during the menstrual cycle an

SUBMITTER: Park SR 

PROVIDER: S-EPMC9279474 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature