Real-time monitoring of serotonin with highly selective aptamer-functionalized conducting polymer nanohybrids.

ABSTRACT: Adequate serotonin levels are pivotal to human well-being; thus, serotonin can be used as a biomarker because it regulates a wide range of physical and psychological functions. As an imbalance of serotonin is highly likely to initiate the pathogenesis of various disorders, monitoring serotonin levels in real time is in high demand for the early detection of disease. We fabricated a field-effect transistor (FET) biosensor based on aptamer-immobilized conducting polymer nanohybrids, which showed an instantaneous response toward serotonin in solution. The mechanism of serotonin detection was based on aptamer deformation after aptamer-ligand interaction and the consequential decrease in the charge carrier density of the FET template. Docking simulations with AutoDock/Vina and PyMOL were succes

SUBMITTER: Lim SG 

PROVIDER: S-EPMC9279540 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature