Altered Balance of Pro-Inflammatory Immune Cells to T Regulatory Cells Differentiates Symptomatic From Asymptomatic Individuals With Anti-Nuclear Antibodies.

ABSTRACT: Systemic Autoimmune Rheumatic Diseases (SARDs) are characterized by the production of anti-nuclear antibodies (ANAs). ANAs are also seen in healthy individuals and can be detected years before disease onset in SARD. Both the immunological changes that promote development of clinical symptoms in SARD and those that prevent autoimmunity in asymptomatic ANA⁺ individuals (ANA⁺ NS) remain largely unexplored. To address this question, we used flow cytometry to examine peripheral blood immune populations in ANA⁺ individuals, with and without SARD, including 20 individuals who subsequently demonstrated symptom progression. Several immune populations were expanded in ANA⁺ individuals with and without SARD, as compared with ANA^- healthy controls

SUBMITTER: Gupta R 

PROVIDER: S-EPMC9279569 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature