Importin α3 (KPNA3) Deficiency Augments Effortful Reward-Seeking Behavior in Mice.

ABSTRACT: Importin α3 (Gene: Kpna3, the ortholog of human Importin α4) is a member of the importin α family and participates in nucleocytoplasmic transport by forming trimeric complexes between cargo proteins and importin β1. Evidence from human studies has indicated that single nucleotide polymorphisms (SNP) in the KPNA3 gene are associated with the occurrence of several psychiatric disorders accompanied by abnormal reward-related behavior, including schizophrenia, major depression, and substance addiction. However, the precise roles of importin α3 in controlling reward processing and motivation are still unclear. In this study, we evaluated the behavioral effects of Kpna3 knockout (KO) in mice on performance in touchscreen operant chamber-based tasks evaluating simple (fixed-r

SUBMITTER: Aomine Y 

PROVIDER: S-EPMC9279672 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature