Prognostic impact of high-risk factors and KRAS mutation in patients with stage II deficient mismatch repair colon cancer: a retrospective cohort study.

ABSTRACT:

Background

Deficient mismatch repair (dMMR) is associated with a good prognosis in patients with stage II colon cancer and observation is recommended after surgery in these patients. In contrast, patients with high-risk factors and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation is associated with a poor prognosis in colon cancer. However, the prognosis and treatment of patients with dMMR colon cancer combined with high-risk factors or KRAS mutation remains unclear. This study aimed to evaluate whether patients with dMMR colon cancer combined with high-risk factors or KRAS mutation require further treatment.

Methods

This single-center retrospective study included patients who received radical surgical resection and mismatch repair (MMR) immuno

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9279762 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature