Bioinformatics analysis of SOXF family genes reveals potential regulatory mechanism and diagnostic value in cancers.

ABSTRACT:

Background

SOXF family genes (SOX7, SOX17, SOX18) have been reported to involved in tumorigenesis and development in previous articles, separately. But data sources, analysis contents and criteria are not same. Here, we focused on SOXF genes to analyze the regulatory mechanisms and diagnostic value at the same standards.

Methods

This study analyzed functions, expressions, methylations, and mutations of SOXF genes through public databases including Metascape, Gene Expression Profiling Interactive Analysis (GEPIA), cBioPortal, Tumor IMmune Estimation Resource (TIMER), and Kaplan-Meier Plotter. TIMER applies a deconvolution method to infer the abundance of tumor-infiltrating immune cells (TIICs) from gene expression profiles. Metascape combines several biological functio

SUBMITTER: Wu D 

PROVIDER: S-EPMC9279774 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature