Identification of the key genes in chronic obstructive pulmonary disease by weighted gene co-expression network analysis.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is prevalent mainly in older adults, especially those who are smokers. It appears to be regulated by multiple genes, but there is some degree of familial clustering. The evidence to date suggests that COPD-associated biomarkers are largely inadequate for disease diagnosis, so we conducted a comprehensive search for more specific genetic markers.

Methods

We used 3 datasets from the Gene Expression Omnibus (GEO) database. By investigating the biological information [i.e., Gene Ontology, Kyoto Encyclopedia of Genes and Genomes and weighted gene co-expression network analysis (WGCNA)], we filtered out 8 differentially expressed genes (DEGs) and validated the transcript levels of those hub genes in 16HBE cell lines, THP-1 ce

SUBMITTER: Xie Z 

PROVIDER: S-EPMC9279780 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature