The effects of dexmedetomidine on the cognitive function of mild cognitive impairment (MCI) rats.

ABSTRACT:

Background

The study sought to investigate the effects of dexmedetomidine (DEX) on cognitive function after anesthesia and to examine its actual mechanism.

Methods

A total of 48 rats were injected with d-galactose (D-gal) 1,000 mg·kg^-1·d^-1 and normal saline at the neck and back for 1 week to establish rats with mild cognitive impairment (MCI) and conduct behavioral tests. Sevoflurane was inhaled and DEX was pumped into each group respectively. Morris water maze (MWM) test was conducted 24 hours later. The inflammatory factors interleukin (IL)-1, interleukin (IL)-6, and a tumor necrosis factor (TNF)-α in brain homogenate were quantitatively measured by enzyme-linked immunosorbent assay (ELISA) on the next day. The apoptosis of hippocampal cells was obser

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC9279787 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature