Narrative review of the relationship between the maternal-fetal interface immune tolerance and the onset of preeclampsia.

ABSTRACT:

Background and objective

The establishment of maternal-fetal interface immune tolerance is essential for successful pregnancy. Studies have shown that spontaneous abortion, recurrent abortion, and fetal growth restriction are related to maternal-fetal interface immune dysfunction. Preeclampsia is an idiopathic condition related to pregnancy which manifests as hypertension, proteinuria, and other target organ damage after 20 weeks of gestation. Although the etiology of preeclampsia is still unknown, its pathogenesis is thought to be related to genetics, environment, and metabolism. In recent years, more and more studies have been conducted on the mechanism of immune tolerance at the maternal-fetal interface and the relationship between immune dysregulation and the pathogenesis of pr

SUBMITTER: Luo F 

PROVIDER: S-EPMC9279811 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature