Bioinformatics analysis combined with experiments to verify potential autophagy genes in wound healing.

ABSTRACT:

Background

The skin is the most exposed tissue and has multiple functions. Wound healing is a major medical problem due to trauma and pathophysiological alterations suffered by patients. The aim of the present study was to search for potential autophagy genes associated with wound healing.

Methods

The GSE168760 dataset was obtained from the Gene Expression Omnibus (GEO) database, and sequencing results were obtained for 14 patient traumas at different time periods. Differentially expressed gene (DEG) analysis, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed. Immune cell and correlation analysis were performed for autophagy genes and DEGs. Peripheral blood was collected from patients at different time periods and Weste

SUBMITTER: Wu YF 

PROVIDER: S-EPMC9279812 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature