Biological impact of iberdomide in patients with active systemic lupus erythematosus.

ABSTRACT:

Objectives

Iberdomide is a high-affinity cereblon ligand that promotes proteasomal degradation of transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). Pharmacodynamics and pharmacokinetics of oral iberdomide were evaluated in a phase 2b study of patients with active systemic lupus erythematosus (SLE).

Methods

Adults with autoantibody-positive SLE were randomised to placebo (n=83) or once daily iberdomide 0.15 mg (n=42), 0.3 mg (n=82) or 0.45 mg (n=81). Pharmacodynamic changes in whole blood leucocytes were measured by flow cytometry, regulatory T cells (Tregs) by epigenetic assay, plasma cytokines by ultrasensitive cytokine assay and gene expression by Modular Immune Profiling.

Results

Iberdomide exhibited linear pharmacokinetics and dose-dependently

SUBMITTER: Lipsky PE 

PROVIDER: S-EPMC9279852 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature