Development and validation of apoptosis-related signature and molecular subtype to improve prognosis prediction in osteosarcoma patients.

ABSTRACT:

Background

Previous evidence has shown that apoptosis performs integral functions in the tumorigenesis and development of various tumors. Therefore, this study aimed to establish a molecular subtype and prognostic signature based on apoptosis-related genes (ARGs) to understand the molecular mechanisms and predict prognosis in patients with osteosarcoma.

Methods

The GEO and TARGET databases were utilized to obtain the expression levels of ARGs and clinical information of osteosarcoma patients. Consensus clustering analysis was used to explore the different molecular subtypes based on ARGs. GO, KEGG, GSEA, ESTIMATE, and ssGSEA analyses were performed to examine the differences in biological functions and immune characteristics between the distinct molecular subtypes. Then, we

SUBMITTER: Hong J 

PROVIDER: S-EPMC9280000 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature