Pemafibrate Prevents Rupture of Angiotensin II-Induced Abdominal Aortic Aneurysms.

ABSTRACT:

Background

Abdominal aortic aneurysm (AAA) is a life-threatening disease that lacks effective preventive therapies. This study aimed to evaluate the effect of pemafibrate, a selective peroxisome proliferator-activated receptor alpha (PPARα) agonist, on AAA formation and rupture.

Methods

Experimental AAA was induced by subcutaneous angiotensin II (AngII) infusion in ApoE ^{- / -} mice for 4 weeks. Pemafibrate (0.1 mg/kg/day) was administered orally. Dihydroethidium staining was used to evaluate the reactive oxygen species (ROS).

Results

The size of the AngII-induced AAA did not differ between pemafibrate- and vehicle-treated groups. However, a decreased mortality rate due to AAA rupture was observed in pemafibrate-treated mic

SUBMITTER: Amioka N 

PROVIDER: S-EPMC9280056 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature