Dataset Information

Genetic Polymorphisms and Kidney Stones Around the Globe: A Systematic Review and Meta-Analysis.

ABSTRACT: Objective: This study explores associations between recurrent kidney stones and genetic polymorphisms. Methods: Meta-analysis of polymorphisms in renal stone cases versus control groups. Four electronic databases (PubMed, SCOPUS, EMBASE, and Web of Science) were searched up to 30 May 2021, using the keywords: "kidney stone" or "kidney calculi," or "urolithiasis" or "nephrolithiasis" or "urinary calculi" and "genome" or "genetic" or "mutation" or "single nucleotide polymorphism." Forrest plots, ORs, 95% CI, Chi-square (χ2)-test, and index of heterogeneity (I2) were calculated. Only studies with Newcastle-Ottawa scale (NOS) ≥ 6 were included for quality control, and Funnel, Begg's, and Eager's plots assessed publication bias. PROSPERO: CRD42022250427. Results: Among 7,671 searched articles, 72 were included. Polymorphisms in VDR (OR: 1.20; 95% CI: 1.06-1.36), CASR (OR = 1.24; 95% CI: 1.01-1.52), Osteopontin (OR = 1.38; 95% CI: 1.09-1.74), and Urokinase genes (OR = 1.52; 95% CI: 1.02-2.28) showed a significant association with risk of urinary stone formation, while Klotho gene showed a protective effect (OR = 0.75; 95% CI: 0.57-0.99). The VDR gene polymorphism was frequent in Asians, whereas CASR polymorphism was frequent in European and North American populations. Conclusion: Multifactorial nature of the stone formation, emphasizing the role of environmental factors, might explain contradictory results in the literature. While polymorphisms in VDR, CASR, Osteopontin, and Urokinase genes were associated with urinary stone formation, the Klotho gene showed a protective effect.

SUBMITTER: Mohammadi A

PROVIDER: S-EPMC9280078 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Genetic Polymorphisms and Kidney Stones Around the Globe: A Systematic Review and Meta-Analysis.

Mohammadi Abdolreza A Shabestari Alireza Namazi AN Baghdadabad Leila Zareian LZ Khatami Fatemeh F Reis Leonardo Oliveira LO Pishkuhi Mahin Ahmadi MA Kazem Aghamir Seyed Mohammad SM

Frontiers in genetics 20220630

<b>Objective:</b> This study explores associations between recurrent kidney stones and genetic polymorphisms. <b>Methods:</b> Meta-analysis of polymorphisms in renal stone cases versus control groups. Four electronic databases (PubMed, SCOPUS, EMBASE, and Web of Science) were searched up to 30 May 2021, using the keywords: "kidney stone" or "kidney calculi," or "urolithiasis" or "nephrolithiasis" or "urinary calculi" and "genome" or "genetic" or "mutation" or "single nucleotide polymorphism." Fo ...[more]

PMID: 35846117

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Dataset Information

Genetic Polymorphisms and Kidney Stones Around the Globe: A Systematic Review and Meta-Analysis.

Publications

Genetic Polymorphisms and Kidney Stones Around the Globe: A Systematic Review and Meta-Analysis.

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