RPS3 Promotes the Metastasis and Cisplatin Resistance of Adenoid Cystic Carcinoma.

ABSTRACT:

Background

Adenoid cystic carcinoma (ACC) is a malignant tumor in salivary gland tissue, that is characterized by strong invasiveness and lung metastasis, leading to poor survival rates. RPS3 is been reported to be associated with the biological functions of tumor cells. This study explored the regulatory effect of RPS3 in ACC to provide new therapeutic targets for ACC therapy.

Methods

We reviewed the clinical and pathologic data of 73 ACC patients. The expression of RPS3 was examined in ACC by immunohistochemistry. Transwell, wound healing, half-maximal inhibitory concentration (IC50) and other experiments were used to determine the regulatory effect of RPS3 on ACC functions. Coimmunoprecipitation and mass spectrometry analysis were used to detect the binding proteins of RP

SUBMITTER: Rui X 

PROVIDER: S-EPMC9280127 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature