Metabolic Profiling at COVID-19 Onset Shows Disease Severity and Sex-Specific Dysregulation.

ABSTRACT:

Background

metabolic changes through SARS-CoV-2 infection has been reported but not fully comprehended. This metabolic dysregulation affects multiple organs during COVID-19 and its early detection can be used as a prognosis marker of severity. Therefore, we aimed to characterize metabolic and cytokine profile at COVID-19 onset and its relationship with disease severity to identify metabolic profiles predicting disease progression.

Material and methods

we performed a retrospective cross-sectional study in 123 COVID-19 patients which were stratified as asymptomatic/mild, moderate and severe according to the highest COVID-19 severity status, and a group of healthy controls. We performed an untargeted plasma metabolic profiling (gas chromatography and capillary electrophoresis-m

SUBMITTER: Ceballos FC 

PROVIDER: S-EPMC9280146 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature