Development of antidiabetic drugs from benzamide derivatives as glucokinase activator: A computational approach.

ABSTRACT: Hyperglycemia is a condition known for the impairment of insulin secretion and is responsible for diabetes mellitus. Various small molecule inhibitors have been discovered as glucokinase activators. Recent studies on benzamide derivatives showed their importance in the treatment of diabetes as glucokinase activator. The present manuscript showed a computation study on benzamide derivatives to help in the production of potent glucokinase activators. In the present study, pharmacophore development, 3D-QSAR, and docking studies were performed on benzamide derivatives to find out the important features required for the development of a potential glucokinase activator. The generated pharmacophore hypothesis ADRR_1 consisted of essential features required for the activity. The resultant statisti

SUBMITTER: Ali A 

PROVIDER: S-EPMC9280248 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature