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Copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines.

ABSTRACT: An efficient three-component one-pot and operationally simple cascade of 2-aminopyridines with sulfonyl azides and terminal ynones is reported, providing a variety of polysubstituted imidazo[1,2-a]pyridine derivatives in moderate to excellent yields. In particular, the reaction goes a through CuAAC/ring-cleavage process and forms a highly active intermediate α-acyl-N-sulfonyl ketenimine with base free.

SUBMITTER: Zhou Z

PROVIDER: S-EPMC9280286 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines.

Zhou Zitong Z Luo Danyang D Li Guanrong G Yang Zhongtao Z Cui Liao L Yang Weiguang W

RSC advances 20220714 31

An efficient three-component one-pot and operationally simple cascade of 2-aminopyridines with sulfonyl azides and terminal ynones is reported, providing a variety of polysubstituted imidazo[1,2-a]pyridine derivatives in moderate to excellent yields. In particular, the reaction goes a through CuAAC/ring-cleavage process and forms a highly active intermediate α-acyl-N-sulfonyl ketenimine with base free. ...[more]

PMID: 35919587

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