Characterization of ADME Gene Variation in Colombian Population by Exome Sequencing.

ABSTRACT: In genes related to drug pharmacokinetics, molecular variations determine interindividual variability in the therapeutic efficacy and adverse drug reactions. The assessment of single-nucleotide variants (SNVs) is used with growing frequency in pharmacogenetic practice, and recently, high-throughput genomic analyses obtained through next-generation sequencing (NGS) have been recognized as powerful tools to identify common, rare and novel variants. These genetic profiles remain underexplored in Latin-American populations, including Colombia. In this study, we investigated the variability of 35 genes included in the ADME core panel (absorption, distribution, metabolism, and excretion) by whole-exome sequencing (WES) of 509 unrelated Colombian individuals with no previous reports of adverse dr

SUBMITTER: Silgado-Guzman DF 

PROVIDER: S-EPMC9280300 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature