Causality Analysis to the Abnormal Subcortical-Cortical Connections in Idiopathic-Generalized Epilepsy.

ABSTRACT: Idiopathic generalized epilepsy (IGE) was characterized by 3-6 Hz generalized spike-wave discharges (GSWDs), and extensive altered interactions in subcortical-cortical circuit. However, the dynamics and the causal relationship among these interactions were less studied. Using resting-state functional magnetic resonance imaging (fMRI) data, the abnormal connections in the subcortical-cortical pathway in IGE were examined. Then, we proposed a novel method of granger causal analysis based on the dynamic functional connectivity, and the predictive effects among these abnormal connections were calculated. The results showed that the thalamus, and precuneus were key regions representing abnormal functional network connectivity (FNC) in the subcortical-cortical circuit. Moreover, the connectivity

SUBMITTER: Qin Y 

PROVIDER: S-EPMC9280354 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature