Breast milk-derived extracellular vesicle miRNAs are associated with maternal asthma and atopy.

ABSTRACT: Background: Breast milk-derived extracellular vesicle (EV) miRNAs may program child health outcomes associated with maternal asthma and atopy. The authors investigated associations between maternal asthma/atopy and EV miRNAs in the Programming of Intergenerational Stress Mechanisms cohort. Methods: Breast milk-derived EV miRNAs collected 6.1 ± 5.9 weeks postnatally (n = 80 mothers) were profiled using the TaqMan OpenArray Human MicroRNA Panel. The authors assessed associations using adjusted robust regression. Results: Nine EV miRNAs were associated with asthma during pregnancy (a priori criteria: nominal p < 0.05; |B_regression| >0.2). miR-1290 was associated with asthma and atopy during pregnancy (p < 0.05; |B_regression| >0.2

SUBMITTER: Bozack AK 

PROVIDER: S-EPMC9280402 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature