Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples.

ABSTRACT: Glycans expand the structural complexity of proteins by several orders of magnitude, resulting in a tremendous analytical challenge when including them in biomedical research. Recent glycobiological research is painting a picture in which glycans represent a crucial structural and functional component of the majority of proteins, with alternative glycosylation of proteins and lipids being an important regulatory mechanism in many biological and pathological processes. Since interindividual differences in glycosylation are extensive, large studies are needed to map the structures and to understand the role of glycosylation in human (patho)physiology. Driven by these challenges, methods have emerged, which can tackle the complexity of glycosylation in thousands of samples, also known as high

SUBMITTER: de Haan N 

PROVIDER: S-EPMC9280525 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature