Genotyping of Dombrock blood group system in blood donors from Saudi Arabia: A single-center study.

ABSTRACT:

Objectives

To establish the frequency of Dombrock (DO) blood group genotypes in Western Saudi Arabians and to compare the findings with other populations in the 1000 genomes database.

Methods

This cross-sectional study was carried out between December 2018 and February 2019. A total of 440 blood samples in ethylenediaminetetraacetic acid tubes were collected from unrelated Saudi Arabian blood donors from Jeddah, Saudi Arabia. Deoxyribonucleic acid was extracted, followed by an allele-specific polymerase chain reaction for DO*01 and DO*02 alleles (c.793A>G, rs11276). The allele and genotype frequencies were counted and compared to those in other populations using the Chi-squared test with Bonferroni adjustments.

Results

The DO allele frequencies for blood

SUBMITTER: Bawazir WM 

PROVIDER: S-EPMC9280534 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature