Significance of TP53 Mutational Status-Associated Signature in the Progression and Prognosis of Endometrial Carcinoma.

ABSTRACT:

Background

TP53 mutations are associated with poor outcome for patients with endometrial carcinoma (EC). However, to date, there have been no studies focused on the construction of TP53 mutational status-associated signature in EC. In this study, we aim to conduct a TP53 mutation-associated prognostic gene signature for EC.

Methods

Hence, we explored the mutational landscape of TP53 in patients with EC based on the simple nucleotide variation data downloaded from The Cancer Genome Atlas (TCGA) database. Differential expression analysis and least absolute shrinkage and selection operator (LASSO)-Cox analysis was used to establish TP53 mutation-associated prognostic gene signature. The overall survival rate between the high-risk and low-risk groups was compared by the Kaplan-M

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9280614 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature