Modulation of mTOR Signaling in Cardiovascular Disease to Target Acute and Chronic Inflammation.

ABSTRACT: Inflammation is a key component in the pathogenesis of cardiovascular diseases causing a significant burden of morbidity and mortality worldwide. Recent research shows that mammalian target of rapamycin (mTOR) signaling plays an important role in the general and inflammation-driven mechanisms that underpin cardiovascular disease. mTOR kinase acts prominently in signaling pathways that govern essential cellular activities including growth, proliferation, motility, energy consumption, and survival. Since the development of drugs targeting mTOR, there is proven efficacy in terms of survival benefit in cancer and allograft rejection. This review presents current information and concepts of mTOR activity in myocardial infarction and atherosclerosis, two important instances of cardiovascular ill

SUBMITTER: Kaldirim M 

PROVIDER: S-EPMC9280721 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature