Inflammation, microbiome and colorectal cancer disparity in African-Americans: Are there bugs in the genetics?

ABSTRACT: Dysregulated interactions between host inflammation and gut microbiota over the course of life increase the risk of colorectal cancer (CRC). While environmental factors and socio-economic realities of race remain predominant contributors to CRC disparities in African-Americans (AAs), this review focuses on the biological mediators of CRC disparity, namely the under-appreciated influence of inherited ancestral genetic regulation on mucosal innate immunity and its interaction with the microbiome. There remains a poor understanding of mechanisms linking immune-related genetic polymorphisms and microbiome diversity that could influence chronic inflammation and exacerbate CRC disparities in AAs. A better understanding of the relationship between host genetics, bacteria, and CRC pathogenesis wil

SUBMITTER: Ahmad S 

PROVIDER: S-EPMC9280725 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature