Identification of potential biomarkers and immune infiltration characteristics in severe asthma.

ABSTRACT:

Objectives

We hope to identify key molecules that can be used as markers of asthma severity and investigate their correlation with immune cell infiltration in severe asthma.

Methods

An asthma dataset was downloaded from the Gene Expression Omnibus database and then processed by R software to obtain differentially expressed genes (DEGs). First, multiple enrichment platforms were applied to analyze crucial biological processes and pathways and protein-protein interaction networks related to the DEGs. We next combined least absolute shrinkage and selection operator logistic regression and the support vector machine-recursive feature elimination algorithms to screen diagnostic markers of severe asthma. Then, a local cohort consisting of 40 asthmatic subjects (24 with moderate as

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC9280849 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature