IGF2 reduces meiotic defects in oocytes from obese mice and improves embryonic developmental competency

ABSTRACT:

Background

Maternal obesity is a global issue that has devastating effects across the reproductive spectrum such as meiotic defects in oocytes, consequently worsening pregnancy outcomes. Different studies have shown that such types of meiotic defects originated from the oocytes of obese mothers. Thus, there is an urgent need to develop strategies to reduce the incidence of obesity-related oocyte defects that adversely affect pregnancy outcomes. Multiple growth factors have been identified as directly associated with female reproduction; however, the impact of various growth factors on female fertility in response to obesity remains poorly understood.

Methods

The immature GV-stage oocytes from HFD female mice were collected and cultured in vitro in two different groups (HF

SUBMITTER: Wan Y 

PROVIDER: S-EPMC9281013 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature