Identification of ENO1 as a prognostic biomarker and molecular target among ENOs in bladder cancer.

ABSTRACT:

Background

Enolase is an essential enzyme in the process of glycolysis and has been implicated in cancer progression. Though dysregulation of ENOs has been reported in multiple cancers, their prognostic value and specific role in bladder cancer (BLCA) remain unclear.

Methods

Multiple databases were employed to examine the expression of ENOs in BLCA. The expression of ENO1 was also validated in BLCA cell lines and tissue samples by western blotting and immunohistochemistry. Kaplan-Meier analysis, ROC curve, univariate and multivariate Cox regression were performed to evaluate the predictive capability of the ENO1. Gene ontology (GO) and Gene Set Enrichment Analyses (GSEA) analysis were employed to perform the biological processes enrichment. Function experiments were performe

SUBMITTER: Huang Z 

PROVIDER: S-EPMC9281045 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature