Maternal-fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study.

ABSTRACT:

Background

Maternal stress before, during and after pregnancy has profound effects on the development and lifelong function of the infant's neurocognitive development. We hypothesized that the programming of the central nervous system (CNS), hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system (ANS) induced by prenatal stress (PS) is reflected in electrophysiological and epigenetic biomarkers. In this study, we aimed to find noninvasive epigenetic biomarkers of PS in the newborn salivary DNA.

Results

A total of 728 pregnant women were screened for stress exposure using Cohen Perceived Stress Scale (PSS), 164 women were enrolled, and 114 dyads were analyzed. Prenatal Distress Questionnaire (PDQ) was also administered to assess specific pregnancy worries. Tra

SUBMITTER: Sharma R 

PROVIDER: S-EPMC9281078 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature