Molecular mimicry between tumor associated antigens and microbiota-derived epitopes.

ABSTRACT:

Background

The gut microbiota profile is unique for each individual and are composed by different bacteria species according to individual birth-to-infant transitions. In the last years, the local and systemic effects of microbiota on cancer onset, progression and response to treatments, such as immunotherapies, has been extensively described. Here we offer a new perspective, proposing a role for the microbiota based on the molecular mimicry of tumor associated antigens by microbiome-associated antigens.

Methods

In the present study we looked for homology between published TAAs and non-self microbiota-derived epitopes. Blast search for sequence homology was combined with extensive bioinformatics analyses.

Results

Several evidences for homology between TAAs and microbi

SUBMITTER: Ragone C 

PROVIDER: S-EPMC9281086 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature