Genetic variants in CYP11B1 influence the susceptibility to coronary heart disease.

ABSTRACT:

Background

Genetic factors are important risk factors to develop coronary heart disease (CHD). In this study, we mainly explored whether CYP11B1 mutations influence CHD risk among Chinese Han population.

Methods

Six variants were genotyped using Agena MassARRAY system from 509 CHD patients and 509 healthy controls. The correlations between CYP11B1 mutations and CHD risk were assessed using odds ratio (OR) and 95% confidence interval (95% CI) by logistic regression. The haplotype analysis and were ultifactor dimensionality reduction (MDR) were conducted.

Results

In the overall analysis, CYP11B1 polymorphisms were not correlated with CHD susceptibility. In the stratified analysis, we found that rs5283, rs6410, and rs4534 are significantly associated with susceptibility

SUBMITTER: Huang X 

PROVIDER: S-EPMC9281100 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature