Systematic prediction of degrons and E3 ubiquitin ligase binding via deep learning.

ABSTRACT:

Background

Degrons are short linear motifs, bound by E3 ubiquitin ligase to target protein substrates to be degraded by the ubiquitin-proteasome system. Mutations leading to deregulation of degron functionality disrupt control of protein abundance due to mistargeting of proteins destined for degradation and often result in pathologies. Targeting degrons by small molecules also emerges as an exciting drug design strategy to upregulate the expression of specific proteins. Despite their essential function and disease targetability, reliable identification of degrons remains a conundrum. Here, we developed a deep learning-based model named Degpred that predicts general degrons directly from protein sequences.

Results

We showed that the BERT-based model performed well in predicti

SUBMITTER: Hou C 

PROVIDER: S-EPMC9281121 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature