Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures.

ABSTRACT:

Purpose

Early accurate diagnosis of infection ± organ dysfunction (sepsis) remains a major challenge in clinical practice. Utilizing effective biomarkers to identify infection and impending organ dysfunction before the onset of clinical signs and symptoms would enable earlier investigation and intervention. To our knowledge, no prior study has specifically examined the possibility of pre-symptomatic detection of sepsis.

Methods

Blood samples and clinical/laboratory data were collected daily from 4385 patients undergoing elective surgery. An adjudication panel identified 154 patients with definite postoperative infection, of whom 98 developed sepsis. Transcriptomic profiling and subsequent RT-qPCR were undertaken on sequential blood samples taken postoperatively from these pa

SUBMITTER: Lukaszewski RA 

PROVIDER: S-EPMC9281215 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature