Persistence of immunity and impact of third dose of inactivated COVID-19 vaccine against emerging variants.

ABSTRACT: This is a comprehensive report on immunogenicity of COVAXIN^® booster dose against ancestral and Variants of Concern (VOCs) up to 12 months. It is well known that neutralizing antibodies induced by COVID-19 vaccines wane within 6 months of vaccination leading to questions on the effectiveness of two-dose vaccination against breakthrough infections. Therefore, we assessed the persistence of immunogenicity up to 6 months after a two or three-dose with BBV152 and the safety of a booster dose in an ongoing phase 2, double-blind, randomized controlled trial (ClinicalTrials.gov: NCT04471519). We report persistence of humoral and cell mediated immunity up to 12 months of vaccination, despite decline in the magnitude of antibody titers. Administration of a third dose of BBV152 increased

SUBMITTER: Vadrevu KM 

PROVIDER: S-EPMC9281359 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature